
| Seth MacFarlane | ... | Stan Smith / ... (54 episodes, 2005-2008) |
 | Wendy Schaal | ... | Francine Smith (54 episodes, 2005-2008) |
 | Rachael MacFarlane | ... | Hayley Smith / ... (53 episodes, 2005-2008) |
 | Scott Grimes | ... | Steve Smith / ... (52 episodes, 2005-2008) |
 | Dee Bradley Baker | ... | Klaus / ... (52 episodes, 2005-2008) |
 | Mike Barker | ... | Terry / ... (22 episodes, 2005-2007) |

| Patrick Stewart | ... | Avery Bullock / ... (18 episodes, 2005-2007) |
 | Mike Henry | ... | Jackson / ... (15 episodes, 2005-2007) |
 | Jeff Fischer | ... | Jeff / ... (14 episodes, 2005-2007) |
 | Daisuke Suzuki | ... | Toshi (14 episodes, 2005-2007) |

| Eddie Kaye Thomas | ... | Barry / ... (14 episodes, 2005-2007) |

| Curtis Armstrong | ... | Snot (13 episodes, 2005-2007) |
 | Matt McKenna | ... | Cap'n Monty / ... (10 episodes, 2005-2007) |

| André Sogliuzzo | ... | Mr. Goodwin / ... (7 episodes, 2005-2008) |

| Chris Diamantopoulos | ... | Bjorn / ... (6 episodes, 2006-2007) |

| Paget Brewster | ... | Thundercat / ... (6 episodes, 2005-2007) |

| Stephen Root | ... | Dick / ... (6 episodes, 2005-2007) |
 | Fred Tatasciore | ... | Police Officer #2 / ... (6 episodes, 2005-2007) |
 | John Di Maggio | ... | Bouncer / ... (5 episodes, 2006-2007) |
 | Martin Mull | ... | Father Donovan (5 episodes, 2005-2007) |

| Jill Talley | ... | Boob Woman / ... (5 episodes, 2005-2006) |

| Kevin Michael Richardson | ... | Principal Lewis / ... (4 episodes, 2005-2006) |

| Ron Livingston | ... | Bob / ... (3 episodes, 2005-2007) |
 | Peter Mackenzie | ... | Chief Shopaholic / ... (3 episodes, 2005-2007) |

| Molly Shannon | ... | Kristy (3 episodes, 2005-2007) |

| Beau Bridges | ... | Lieutenant Thacker / ... (3 episodes, 2005-2006) |

| Elias Koteas | ... | Jim (3 episodes, 2005-2006) |

| Megyn Price | ... | Linda / ... (3 episodes, 2005-2006) |

| Robert Tinkler | ... | Doyle / ... (3 episodes, 2006-2008) |

| Shawn Michael Howard | ... | Homeless Guy (3 episodes, 2006-2007) |
 | Erik Durbin | ... | Counter Man / ... (3 episodes, 2007-2008) |
 | Brian Lally | ... | Amy's Dad / ... (3 episodes, 2007-2008) |

| Masam Holden | ... | Henry (2 episodes, 2007) |

| Raven-Symoné | ... | Katie / ... (2 episodes, 2008) |

| James Patrick Stuart | ... | Bartender (2 episodes, 2005-2007) |

| Seth Green | | (2 episodes, 2005-2008) |
 | Chris Cox | ... | George W. Bush (2 episodes, 2005-2007) |

| Phill Lewis | ... | Duper (2 episodes, 2005-2007) |
 | Terri Lyn Rodriguez | ... | Lindsay / ... (2 episodes, 2005-2007) |
 | Odile Corso | ... | Angelina Jolie / ... (2 episodes, 2005) |
 | Colt .40 Feinberg | ... | Khalid / ... (2 episodes, 2005) |

| Brian George | ... | Ali / ... (2 episodes, 2005) |

| Gina Gershon | ... | American Girl #1 / ... (2 episodes, 2005) |
 | Peter Lurie | ... | Mysterious Man / ... (2 episodes, 2005) |

| Swoosie Kurtz | ... | Betty / ... (2 episodes, 2006-2008) |

| Scott Lowell | ... | Brett / ... (2 episodes, 2006) |

| J. Lee | ... | Black Guy / ... (2 episodes, 2007-2008) |

| Jane Lynch | ... | Al / ... (2 episodes, 2007) |

| Rolando Molina | ... | Meth lab guy / ... (2 episodes, 2007) |
 | Niecy Nash | ... | Angel / ... (2 episodes, 2007) |
|
| Seth MacFarlane | .... | executive producer (59 episodes, 2005-2008) |
| Kara Vallow | .... | producer / animation producer (49 episodes, 2005-2008) |
| Michael Shipley | .... | co-executive producer (32 episodes, 2006-2008) |
| Mike Barker | .... | executive producer (20 episodes, 2006-2008) |
| Matt Weitzman | .... | executive producer (20 episodes, 2006-2008) |
| Diana Ritchey | .... | animation producer / producer: animation (14 episodes, 2007-2008) |
| Kenny Schwartz | .... | co-executive producer / executive producer (11 episodes, 2006-2008) |
| Rick Wiener | .... | co-executive producer / executive producer (11 episodes, 2006-2008) |
| David Zuckerman | .... | co-executive producer / executive producer (11 episodes, 2006-2008) |
| Dan Vebber | .... | supervising producer / producer (10 episodes, 2005-2007) |
| Jim Bernstein | .... | co-executive producer (10 episodes, 2006-2008) |
| Josh Bycel | .... | supervising producer (10 episodes, 2006-2008) |
| Brian Boyle | .... | producer (9 episodes, 2006-2007) |
| Jonathan Fener | .... | supervising producer (9 episodes, 2006-2007) |
| Nahnatchka Khan | .... | producer (9 episodes, 2006-2007) |
| Mark Douglas | .... | associate producer / co-producer (7 episodes, 2007-2008) |
|
| Carter Bays | .... | supervising producer (unknown episodes) |
| Etan Cohen | .... | co-executive producer (unknown episodes) |
| Robert Cohen | .... | consulting producer (unknown episodes) |
| Craig Thomas | .... | supervising producer (unknown episodes) |
| |
|
| John Drake O'Day | .... | storyboard artist (5 episodes, 2006-2007) |
| Catherine Burch Aguilar | .... | prop designer (2 episodes, 2007) |
| Lisa Bergqvist | .... | color key (2 episodes, 2007) |
| Josue Cervantes | .... | storyboard artist (2 episodes, 2007) |
| Paul Cunningham | .... | storyboard revisionist (2 episodes, 2007) |
| Matt Haber | .... | storyboard revisionist (2 episodes, 2007) |
| Zeke Johnson | .... | prop designer (2 episodes, 2007) |
| Pamela Jorden | .... | color key (2 episodes, 2007) |
| Steve Lenze | .... | storyboard revisionist (2 episodes, 2007) |
| Michaelangelo Rocco | .... | storyboard revisionist (2 episodes, 2007) |
| Jessie Romero | .... | storyboard revisionist (2 episodes, 2007) |
| Micky Rose | .... | color key (2 episodes, 2007) |
| Harry Sabin | .... | storyboard revisionist (2 episodes, 2007) |
| Yelena Tokman | .... | color key (2 episodes, 2007) |
| Steve Wong | .... | storyboard revisionist (2 episodes, 2007) |
| Brent Woods | .... | storyboard supervisor (2 episodes, 2007) |
| |
|
| Kevin Thresher | .... | retake director / storyboard artist / ... (16 episodes, 2006-2008) |
| Ashley J. Long | .... | storyboard revisionist (14 episodes, 2007-2008) |
| Tom Welch | .... | assistant to producers: animation / production secretary: animation (10 episodes, 2007-2008) |
| Ron Hughart | .... | supervising director of animation (8 episodes, 2007-2008) |
| Brett Pierce | .... | animation production assistant / production assistant: animation / ... (8 episodes, 2007-2008) |
| Jamie Iglehart | .... | production assistant: animation / animation production assistant (7 episodes, 2007-2008) |
| Ron Brewer | .... | storyboard artist (6 episodes, 2005) |
| Anthony Lioi | .... | supervising director of animation (5 episodes, 2007-2008) |
| Jim Feeley | .... | design supervisor / character design supervisor / ... (5 episodes, 2007) |
| Sean Isroelit | .... | animatic editor (4 episodes, 2007-2008) |
| Harry McLaughlin | .... | animatic editor (4 episodes, 2007-2008) |
| Ray Valenzuela | .... | animatics / animation production assistant (4 episodes, 2007-2008) |
| David Bastian | .... | timing supervisor (3 episodes, 2007-2008) |
| Mike Kalec | .... | animatics (3 episodes, 2007-2008) |
| Jeff Rebner | .... | character designer (3 episodes, 2007-2008) |
| Christine Smith | .... | timing supervisor (3 episodes, 2007-2008) |
| Megan Smithyman | .... | animation production assistant / coordinator: design / ... (3 episodes, 2007) |
| Chris Bennett | .... | assistant director: animation (2 episodes, 2007-2008) |
| Jennifer Graves | .... | assistant director: animation (2 episodes, 2007-2008) |
| Mike L. Mayfield | .... | assistant director: animation (2 episodes, 2007-2008) |
| Eric Fredrickson | .... | storyboard artist (2 episodes, 2007) |
| Thomas Horvath | .... | animation production assistant / production assistant: animation (2 episodes, 2007) |
| George Rincon | .... | animatic production assistant: Animatics / animation production assistant (2 episodes, 2007) |
| Paul Scarlata | .... | storyboard artist (2 episodes, 2007) |
| John Drake O'Day | .... | assistant director: animation (2 episodes, 2008) |
|
| Sheikh 'Ubi' Ubaid Mahmood | .... | animatics (unknown episodes) |
| SoonJin Mooney | .... | animation timer (unknown episodes) |
| Kari Salrin | .... | animatics (unknown episodes) |
| Erin Sirpenski | .... | animatics (unknown episodes) |
| |
|
| Matt Fusfeld | .... | executive assistant / assistant to writer / ... (30 episodes, 2005-2008) |
| Marci Proietto | .... | production executive (28 episodes, 2005-2008) |
| Travis Bowe | .... | executive assistant to producers / assistant: Mike Barker and Matt Weitzman / ... (24 episodes, 2006-2008) |
| Oscar Sosa | .... | first accountant (23 episodes, 2005-2006) |
| Tom Welch | .... | production secretary / assistant to producers (22 episodes, 2006-2008) |
| Thomas Horvath | .... | production assistant (20 episodes, 2006-2008) |
| Katie Krentz | .... | assistant to production executive (11 episodes, 2007-2008) |
| Sarah Peters | .... | executive assistant (10 episodes, 2005-2006) |
| Thomas Horvath II | .... | production assistant (9 episodes, 2006-2007) |
| Adam Catino | .... | production assistant (7 episodes, 2005) |
| Ron Hughart | .... | supervising director (7 episodes, 2007) |
| Anthony Lioi | .... | supervising director (7 episodes, 2007) |
| Eric John Cookmeyer | .... | design coordinator (6 episodes, 2005) |
| Amy Reynolds | .... | production coordinator (6 episodes, 2006-2007) |
| Liz Kelly | .... | production assistant (5 episodes, 2007) |
| Erin Sirpenski | .... | design production assistant (3 episodes, 2005) |
| Gideon Boomer | .... | production assistant (3 episodes, 2007-2008) |
| Mike Kalec | .... | production assistant (3 episodes, 2007-2008) |
| Chris Dallman | .... | assistant: Diana Ritchey and Ron Hughart (3 episodes, 2007) |
| Brett Pierce | .... | production assistant (2 episodes, 2007) |
| Liddane Sanders | .... | production controller (2 episodes, 2007) |
| |