| Angela Lansbury | ... | Jessica Fletcher / ... (264 episodes, 1984-1996) |
 | William Windom | ... | Dr. Seth Hazlitt / ... (53 episodes, 1985-1996) |
| Ron Masak | ... | Sheriff Mort Metzger / ... (41 episodes, 1985-1996) |
| Louis Herthum | ... | Deputy Andy Broom / ... (25 episodes, 1989-1996) |
| Tom Bosley | ... | Sheriff Amos Tupper (19 episodes, 1984-1988) |
| Will Nye | ... | Deputy Floyd McCallum (13 episodes, 1988-1991) |
| Michael Horton | ... | Grady Fletcher (12 episodes, 1984-1995) |
| Ken Swofford | ... | Lt. Catalano / ... (11 episodes, 1985-1992) |
| Herb Edelman | ... | NYPD Lieutenant Artie Gelber / ... (10 episodes, 1984-1995) |
| Julie Adams | ... | Eve Simpson (10 episodes, 1987-1993) |
| Keith Michell | ... | Dennis Stanton (9 episodes, 1988-1993) |
| Bradford Dillman | ... | Arthur Brent / ... (8 episodes, 1985-1995) |
| Gregg Henry | ... | Sheriff Lynn Childs / ... (7 episodes, 1985-1996) |
| Len Cariou | ... | Michael Hagarty / ... (7 episodes, 1985-1992) |
| James Sloyan | ... | Robert Butler / ... (7 episodes, 1986-1991) |
| Rosanna Huffman | ... | Connie Miles / ... (7 episodes, 1984-1994) |
| Alexander Folk | ... | Al, the mailman / ... (7 episodes, 1986-1993) |
| Richard Paul | ... | Mayor Sam Booth (7 episodes, 1986-1991) |
| Hallie Todd | ... | Rhoda Markowitz / ... (7 episodes, 1989-1991) |
| George DiCenzo | ... | Inspector Lombardo / ... (6 episodes, 1984-1994) |
| Gregory Sierra | ... | Lieutenant Gabriel Caceras / ... (6 episodes, 1985-1995) |
| Ken Howard | ... | Hank Shipton / ... (6 episodes, 1985-1994) |
| Jerry Orbach | ... | Harry McGraw / ... (6 episodes, 1985-1991) |
| Joe Dorsey | ... | Ben Devlin / ... (6 episodes, 1986-1990) |
| Richard Beymer | ... | Charles Lawton Standish / ... (6 episodes, 1987-1996) |
| Richardson Morse | ... | Arvin Bucknell / ... (6 episodes, 1987-1996) |
| John Astin | ... | Harry Pierce / ... (5 episodes, 1984-1995) |
| Wayne Rogers | ... | Charlie Garrett (5 episodes, 1993-1995) |
| Mark Lindsay Chapman | ... | Officer Matthew Ryan / ... (5 episodes, 1987-1995) |
| Steve Forrest | ... | Lt. Paul Stratton / ... (5 episodes, 1986-1996) |
| James Sutorius | ... | Lawrence Cayle / ... (5 episodes, 1985-1995) |
| Felicia Lansbury | ... | Moira / ... (5 episodes, 1989-1995) |
| Allan Miller | ... | Charles Crowe / ... (5 episodes, 1985-1995) |
| Robin Bach | ... | Clerk / ... (5 episodes, 1984-1990) |
| Alan Fudge | ... | Brian Wade / ... (5 episodes, 1991-1996) |
| William Lucking | ... | Bo Dixon / ... (5 episodes, 1986-1993) |
| Martin Milner | ... | Clint Phelps / ... (5 episodes, 1985-1996) |
| Ed Nelson | ... | Carl Turnball / ... (5 episodes, 1985-1995) |
| Bruce Gray | ... | Ted Hartley / ... (5 episodes, 1984-1994) |
| Ernie Lively | ... | Hal Palmer / ... (5 episodes, 1990-1996) |
| Madlyn Rhue | ... | Jean O'Neill / ... (5 episodes, 1989-1996) |
| Barbara Babcock | ... | Carol Collins / ... (5 episodes, 1985-1993) |
| Stephen Macht | ... | Attorney Jason Farrell / ... (5 episodes, 1985-1996) |
| Lee Purcell | ... | Maylene Sutter / ... (5 episodes, 1985-1994) |
| Ian Ogilvy | ... | Harold Baines / ... (5 episodes, 1989-1994) |
| Tricia O'Neil | ... | Althea Mayberry / ... (5 episodes, 1984-1991) |
| John Petlock | ... | Man / ... (5 episodes, 1984-1993) |
| Vince Howard | ... | Blanton / ... (5 episodes, 1984-1994) |
| R.J. Adams | ... | Father Markopulos / ... (5 episodes, 1984-1990) |
| Robert Pine | ... | Doug Helman / ... (5 episodes, 1986-1996) |
| Debbie Zipp | ... | Donna Mayberry / ... (5 episodes, 1987-1990) |
| Leonard Lightfoot | ... | Det. Henderson / ... (5 episodes, 1993-1994) |
| Claude Akins | ... | Capt. Ethan Cragg / ... (4 episodes, 1984) |
| Katherine Cannon | ... | Eleanor Revere / ... (4 episodes, 1986-1995) |
| Susan Blakely | ... | Catherine Wayne / ... (4 episodes, 1989-1994) |
| Harry Guardino | ... | Haskell Drake / ... (4 episodes, 1984-1993) |
| Robert Desiderio | ... | Edward Graham / ... (4 episodes, 1986-1994) |
| Taylor Nichols | ... | Drew Finley / ... (4 episodes, 1993-1996) |
| Kristoffer Tabori | ... | Desmond / ... (4 episodes, 1984-1994) |
| Mark Shera | ... | Raymond Carmody / ... (4 episodes, 1985-1988) |
| Sam Anderson | ... | Dan the Electrician / ... (4 episodes, 1993-1996) |
| Frederick Coffin | ... | Lt. Roy Flint / ... (4 episodes, 1989-1996) |
| Jeff Conaway | ... | Howard Griffin / ... (4 episodes, 1984-1994) |
| Lenore Kasdorf | ... | Ally Collins / ... (4 episodes, 1984-1992) |
| Robert Hogan | ... | Dr. Wylie Graham / ... (4 episodes, 1984-1989) |
| Fionnula Flanagan | ... | Eileen O'Bannon / ... (4 episodes, 1987-1995) |
| John McMartin | ... | Gavin Daniels / ... (4 episodes, 1985-1991) |
| Andrew Prine | ... | Gil Blocker / ... (4 episodes, 1984-1991) |
| John Karlen | ... | Superintendent Arthur Joyce / ... (4 episodes, 1989-1995) |
| Gerald S. O'Loughlin | ... | Ben Oliver / ... (4 episodes, 1985-1993) |
| James Stephens | ... | Charles Devon / ... (4 episodes, 1984-1994) |
| Carol Lawrence | ... | Candice Drake / ... (4 episodes, 1984-1995) |
| Mitch Ryan | ... | Capt. Ernest Lenko / ... (4 episodes, 1985-1995) |
| Stuart Whitman | ... | Ben Miller / ... (4 episodes, 1984-1992) |
| Mark Rolston | ... | Sgt. Terence Boyle / ... (4 episodes, 1992-1995) |
| Greg Norberg | ... | Officer #2 / ... (4 episodes, 1984-1990) |
| Shea Farrell | ... | Kevin Tibbles / ... (4 episodes, 1986-1995) |
| Theodore Bikel | ... | Inspector Van Horn / ... (4 episodes, 1987-1994) |
| Chad Everett | ... | Clark Blanchard / ... (4 episodes, 1986-1993) |
| Leslie Easterbrook | ... | Antoinette Fishman / ... (4 episodes, 1988-1995) |
| Pat Harrington Jr. | ... | A.D.A. Mel Comstock / ... (4 episodes, 1985-1991) |
| Gary Lockwood | ... | Harris Talmadge / ... (4 episodes, 1985-1994) |
| Monte Markham | ... | Andrew Gant / ... (4 episodes, 1986-1993) |
| Anne Lockhart | ... | Grace Earl Lamont / ... (4 episodes, 1984-1994) |
| Jessica Walter | ... | Gwen Noble / ... (4 episodes, 1985-1994) |
| Eugene Roche | ... | Billy Simms / ... (4 episodes, 1986-1991) |
| Geoffrey Lewis | ... | Hank Crenshaw / ... (4 episodes, 1987-1996) |
| James Carroll Jordan | ... | Adam Rogers / ... (4 episodes, 1984-1990) |
| Andrew Brye | ... | Ahmed Shankar (4 episodes, 1991-1992) |
| Cassie Yates | ... | Carla Talbot / ... (4 episodes, 1984-1994) |
| Larry Wilcox | ... | Andy Crane / ... (4 episodes, 1986-1992) |
| Christine Belford | ... | Erica Baldwin / ... (4 episodes, 1984-1993) |
| Wings Hauser | ... | Carl / ... (4 episodes, 1985-1996) |
| Laurence Luckinbill | ... | Howard Crane / ... (4 episodes, 1985-1994) |
| Michael Callan | ... | Bart Mahoney / ... (4 episodes, 1987-1994) |
| Michael McGrady | ... | Bo Wilder / ... (4 episodes, 1987-1992) |
| Philip Abbott | ... | Ed Cullen / ... (4 episodes, 1988-1995) |
| Wendy Hoffman | ... | Carol / ... (4 episodes, 1989-1996) |
| David Birney | ... | Earl Harper / ... (4 episodes, 1989-1993) |
| David Stenstrom | ... | Budding Comic / ... (4 episodes, 1989-1993) |
| Robert Curtis Brown | ... | Bud Forbes / ... (3 episodes, 1994-1996) |
| Lisa Darr | ... | Carrie Benton / ... (3 episodes, 1994-1996) |
| Ross Kettle | ... | Ian O'Bannon / ... (3 episodes, 1995) |
| Charles Napier | ... | Hank Sutter / ... (3 episodes, 1986-1995) |
| Rod Taylor | ... | Inspector Rory Lanahan / ... (3 episodes, 1995) |
| Ken Sansom | ... | Bert, the Desk Clerk / ... (3 episodes, 1985-1986) |
| Eddie Barth | ... | Richie Kanpinski / ... (3 episodes, 1984-1994) |
| David Ackroyd | ... | Bert Lown / ... (3 episodes, 1986-1994) |
| Bruce Abbott | ... | Drew Granger / ... (3 episodes, 1991-1995) |
| Leslie Bevis | ... | Andrea Nader / ... (3 episodes, 1995) |
| Grant Goodeve | ... | Ben Skyler / ... (3 episodes, 1984-1988) |
| Ramon Bieri | ... | Capt. Frank Browning / ... (3 episodes, 1985-1990) |
| Warren Berlinger | ... | Coach Pat Patillo / ... (3 episodes, 1985-1989) |
| Doran Clark | ... | Becky Anderson / ... (3 episodes, 1984-1992) |
| Lonny Chapman | ... | Addison Langley / ... (3 episodes, 1985-1993) |
| Bryan Cranston | ... | Brian East / ... (3 episodes, 1986-1996) |
| Corinne Bohrer | ... | Bea Huffington / ... (3 episodes, 1992-1996) |
| Robert Costanzo | ... | Det. Lt. Greco / ... (3 episodes, 1986-1995) |
| Peter Donat | ... | David North / ... (3 episodes, 1989-1994) |
| John D'Aquino | ... | J. Peter Carmody / ... (3 episodes, 1992-1996) |
| Mike Connors | ... | Boyce Brown / ... (3 episodes, 1989-1995) |
| Paul Gleason | ... | Lt. Barney Claymore / ... (3 episodes, 1989-1992) |
| Ben Masters | ... | Chief Gillis / ... (3 episodes, 1990-1994) |
| Norman Lloyd | ... | Edward St. Cloud / ... (3 episodes, 1986-1993) |
| Rosanna DeSoto | ... | Consuela Schaeffer / ... (3 episodes, 1988-1996) |
| Van Johnson | ... | Daniel Hannigan / ... (3 episodes, 1984-1990) |
| Marilyn Jones | ... | Bridie Harmon / ... (3 episodes, 1988-1994) |
| David Lansbury | ... | Bradley 'Brad' Hellman / ... (3 episodes, 1991-1993) |
| Richard Libertini | ... | Carson Robbins / ... (3 episodes, 1993-1996) |
| Hurd Hatfield | ... | Jean-Pierre Dusant / ... (3 episodes, 1984-1989) |
| Clu Gulager | ... | Carl Mestin / ... (3 episodes, 1985-1987) |
| Brian McNamara | ... | Harry Neville / ... (3 episodes, 1991-1995) |
| Jerry Hardin | ... | Hamish McPherson / ... (3 episodes, 1994-1996) |
| John Saxon | ... | Bernardo Bonelli / ... (3 episodes, 1984-1994) |
| Dakin Matthews | ... | Buford Hazlitt / ... (3 episodes, 1992-1995) |
| Morgan Stevens | ... | Nick Fulton / ... (3 episodes, 1984-1987) |
| Lyman Ward | ... | Colin Crowe / ... (3 episodes, 1991-1995) |
| Michael Zelniker | ... | Harley Foote / ... (3 episodes, 1993-1996) |
| Christopher Neame | ... | Dr. John Sullivan / ... (3 episodes, 1993-1995) |
| Sandy Ward | ... | Barnes / ... (3 episodes, 1984-1993) |
| Raphael Sbarge | ... | Peter Franklin / ... (3 episodes, 1990-1995) |
| Gregory Walcott | ... | Isaiah Potts / ... (3 episodes, 1984-1991) |
| Ed Morgan | ... | Austin Bailey / ... (3 episodes, 1984-1993) |
| Mario Machado | ... | Anchor / ... (3 episodes, 1985-1995) |
| Harry Stephens | ... | Neal / ... (3 episodes, 1984-1986) |
| Tony Ballen | ... | Bookie #1 / ... (3 episodes, 1984-1987) |
| William Atherton | ... | Greg Dalton / ... (3 episodes, 1985-1991) |
| Vincent Baggetta | ... | Antonio Carboni / ... (3 episodes, 1985-1990) |
| Lloyd Bochner | ... | Dr. Terence Mayhew / ... (3 episodes, 1986-1992) |
| Daphne Ashbrook | ... | Alexis Hill / ... (3 episodes, 1990-1995) |
| Jay Acovone | ... | Det. Sgt. Vinnie Grillo / ... (3 episodes, 1990-1994) |
| George Grizzard | ... | Dr. Aubrey Benton / ... (3 episodes, 1985-1988) |
| Christopher Allport | ... | Donald Granger / ... (3 episodes, 1986-1994) |
| Ray Girardin | ... | Lt. Casey / ... (3 episodes, 1986-1987) |
| Michael Beck | ... | Brian Bentall / ... (3 episodes, 1989-1993) |
| Ismael 'East' Carlo | ... | Frank Fernandez / ... (3 episodes, 1992-1994) |
| Genie Francis | ... | Victoria Brandon / ... (3 episodes, 1984-1990) |
| Linda Kelsey | ... | Diana Simms / ... (3 episodes, 1985-1996) |
| David Groh | ... | Dr. Stan Garfield / ... (3 episodes, 1985-1991) |
| George Furth | ... | Farley / ... (3 episodes, 1987-1992) |
| Cliff De Young | ... | Carlton Reid / ... (3 episodes, 1988-1992) |
| Lois Nettleton | ... | Amelia / ... (3 episodes, 1984-1991) |
| Joseph Cali | ... | Paul Grimaldi / ... (3 episodes, 1985-1994) |
| Leann Hunley | ... | Dana Darren / ... (3 episodes, 1988-1994) |
| Conrad Janis | ... | Dr. Yambert / ... (3 episodes, 1984-1991) |
| Anne Francis | ... | Lee Haley / ... (3 episodes, 1984-1990) |
| Marilyn Hassett | ... | Barbara Blair / ... (3 episodes, 1984-1988) |
| Larry Linville | ... | Lt. Steven Ames / ... (3 episodes, 1985-1995) |
| Linda Purl | ... | Crystal Wendle / ... (3 episodes, 1985-1993) |
| Nicholas Pryor | ... | David Kingston / ... (3 episodes, 1985-1991) |
| Pat Hingle | ... | Lt. James Ignatius O'Malley / ... (3 episodes, 1986-1991) |
| Robert Lipton | ... | Colin Hale / ... (3 episodes, 1985-1989) |
| Jon Cypher | ... | Capt. Rory O'Neil / ... (3 episodes, 1986-1993) |
| David Hedison | ... | Victor Casper / ... (3 episodes, 1986-1989) |
| Kate Mulgrew | ... | Joanna Rollins / ... (3 episodes, 1987-1994) |
| Peter Van Norden | ... | CIA Agt. Dennis Quinlan / ... (3 episodes, 1989-1996) |
| George Hearn | ... | Elliott Von Stuben / ... (3 episodes, 1990-1992) |
| Sean O'Bryan | ... | Charlie D. McCumber / ... (3 episodes, 1992-1995) |
| Robert Vaughn | ... | Charles Winthrop / ... (3 episodes, 1985-1992) |
| Jeff Yagher | ... | Dep. Wayne Beeler / ... (3 episodes, 1987-1993) |
| Nicolas Surovy | ... | Ben Judson / ... (3 episodes, 1992-1996) |
| Dack Rambo | ... | Arnold Hastings / ... (3 episodes, 1984-1990) |
| Fritz Weaver | ... | Edwin Dupont / ... (3 episodes, 1985-1987) |
| Pamela Susan Shoop | ... | Katie McCallum / ... (3 episodes, 1986-1992) |
| Michael Tolan | ... | Lt. Alan Terwilliger / ... (3 episodes, 1987-1994) |
| Jamie Rose | ... | Anne Lowery / ... (3 episodes, 1988-1993) |
| Robert Knepper | ... | Charles George Drexler / ... (3 episodes, 1993-1996) |
| Stan Shaw | ... | Detective Sergeant Laughton / ... (3 episodes, 1985-1994) |
| Lawrence Pressman | ... | George Reed / ... (3 episodes, 1985-1993) |
| Kevin McCarthy | ... | Milton Porter / ... (3 episodes, 1985-1992) |
| Robert Reed | ... | Adrian Winslow / ... (3 episodes, 1985-1990) |
| Glynn Turman | ... | Ben Coleman / ... (3 episodes, 1985-1989) |
| David Ogden Stiers | ... | Aubrey Thornton / ... (3 episodes, 1986-1996) |
| Carolyn Seymour | ... | Alice Montrose / ... (3 episodes, 1987-1995) |
| Efrem Zimbalist Jr. | ... | Adam Quatrain / ... (3 episodes, 1988-1992) |
| Roy Thinnes | ... | J. K. Davern / ... (3 episodes, 1985-1991) |
| George Wyner | ... | Dr. Lewis / ... (3 episodes, 1988-1995) |
| Lyle Waggoner | ... | Ben Wright / ... (3 episodes, 1984-1993) |
| Carol Swarbrick | ... | Deputy Emma / ... (3 episodes, 1984-1990) |
| Mark Costello | ... | Guard / ... (3 episodes, 1985-1992) |
| James Bartz | ... | Jonathan Fisk / ... (3 episodes, 1986-1995) |
| Rick Dano | ... | Detective Boyd / ... (3 episodes, 1994-1996) |
| Jim Bockelman | ... | Fifth Bud / ... (3 episodes, 1993-1996) |
| Gerald York | ... | Buddy #2 / ... (3 episodes, 1985-1987) |
| Paul Ryan | ... | Entertainment Reporter / ... (3 episodes, 1984-1992) |
| Danny McCoy Jr. | ... | Father Hank / ... (3 episodes, 1985-1996) |
| Diana Canova | ... | Annie Lawson / ... (3 episodes, 1984-1996) |
| Elaine Joyce | ... | Cathy Haley / ... (3 episodes, 1984-1993) |
| Olivia Cole | ... | Callie Coleman / ... (3 episodes, 1985-1995) |
| Lee Meriwether | ... | Grace Overholtz / ... (3 episodes, 1985-1995) |
| Evelyn Keyes | ... | Edna / ... (3 episodes, 1985-1993) |
| Vera Miles | ... | Charmaine Calloway Thompson / ... (3 episodes, 1985-1991) |
| Florence Henderson | ... | Maria Morgana / ... (3 episodes, 1986-1990) |
| Karen Hensel | ... | Dep. Mary Jo Rush / ... (3 episodes, 1987-1996) |
| Charles Hoyes | ... | Carney / ... (3 episodes, 1987-1995) |
| Steve Inwood | ... | Cash Logan / ... (3 episodes, 1987-1995) |
| Tom Hallick | ... | D.A. Randall Thompson / ... (3 episodes, 1987-1994) |
| Charles Siebert | ... | Don Sims / ... (3 episodes, 1987-1994) |
| Diane Baker | ... | Anna Louise Barlow / ... (3 episodes, 1987-1992) |
| Judith Chapman | ... | Dr. Jayne Honig / ... (3 episodes, 1987-1992) |
| Zale Kessler | ... | Cook / ... (3 episodes, 1987-1992) |
| Kenny Davis | ... | Fisherman / ... (3 episodes, 1987-1991) |
| Robin Dearden | ... | Gail Manning / ... (3 episodes, 1987-1991) |
| Sandy McPeak | ... | Bill Spenser / ... (3 episodes, 1987-1990) |
| Guy Stockwell | ... | Dorn Van Stotter / ... (3 episodes, 1987-1990) |
| Gloria DeHaven | ... | Phyllis Grant (3 episodes, 1987-1989) |
| Kathryn Grayson | ... | Ideal Molloy (3 episodes, 1987-1989) |
| Sally Klein | ... | Corinne (3 episodes, 1987-1989) |
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